PDE4D Gene - GeneCards | PDE4D Protein | PDE4D Antibody
PDE4D has been reported to be involved in CFTR by binding to Shank2 (scaffolding protein), indicating that PDE4D may be involved in mediating this effect through PDE4 inhibition (Ji et al. 2007). Moreover, PDE4 inhibition is known to cause serotonin receptor 5HT4-mediated Ach release, prompting contraction of circular smooth muscle in the ...
PDE4D - Wikipedia
Exploring the role of PDE4 isoenzymes in hypertension is vital to the development of new treatment strategies. As a second messenger, cAMP is related to cardiovascular diseases: cardiac fibrosis ...
Design of phosphodiesterase 4D (PDE4D) allosteric modulators ... - Nature
Abstract. Cyclic adenosine monophosphate (cAMP) is one of the second messengers critically involved in the molecular mechanisms underlying memory formation. In the CNS, the availability of cAMP is tightly controlled by phosphodiesterase 4 (PDE4), a family of enzymes that degrades the cyclic nucleotide to inactive AMP.
PDE4 Subtypes in Cancer - PMC - National Center for Biotechnology ...
We have systematically investigated PDE4A, PDE4B, PDE4C, and PDE4D isoforms and found evidence associating them with several cancer types including hematologic malignancies and lung cancers, among others.
PDE4 subtypes in cancer | Oncogene - Nature
GeneCards Summary for PDE4D Gene. PDE4D (Phosphodiesterase 4D) is a Protein Coding gene. Diseases associated with PDE4D include Acrodysostosis 2 With Or Without Hormone Resistance and Acrodysostosis . Among its related pathways are GPCR downstream signalling and Sweet Taste Signaling .
Phosphodiesterase 4D: an enzyme to remember - PMC - National Center for ...
cAMP-specific 3',5'-cyclic phosphodiesterase 4D is an enzyme that in humans is encoded by the PDE4D gene. Function [ edit ] The PDE4D gene is complex and has at least 9 different isoforms that encode functional proteins.
Role of phosphodiesterases in the pathophysiology of ... - Nature
PDE4D consists of at least nine protein isoforms that all possess the phosphodiesterase catalytic domain in the carboxyl terminus and are categorized into one of the so-called "long," "short," and "supershort" forms (reviewed in ref. 11 ).
Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D ...
Phosphodiesterase 4 (PDE4) has four isoforms (PDE4A-D) with at least 25 splice variants. PDE4 subtype nonselective inhibitors produce potent antidepressant-like and cognition-enhancing effects via...
Genomic and functional characterizations of phosphodiesterase ... - PNAS
PDE4 enzyme is predominant amongst the 11 PDE super-family enzymes and has four isoforms - PDE4A, PDE4B, PDE4C and PDE4D. PDEs interact with myomegalin (a structural protein), which is highly expressed in skeletal and cardiac muscles and play crucial role in cardiac contractility [3].
Insight into Inhibitory Mechanism of PDE4D by Dietary Polyphenols Using ...
To optimize PDE4D selectivity, we explored fluoro-substituted derivatives that could provide favorable electrostatic interactions with the partially positively charged edge of Phe196 in PDE4D.